منابع مشابه
Pathogenesis of obstructive sleep apnea.
The pathogenesis of obstructive sleep apnea (OSA) has been under investigation for over 25 years, during which a number of factors that contribute to upper airway (UA) collapse during sleep have been identified. Structural/anatomic factors that constrict space for the soft tissues surrounding the pharynx and its lumen are crucial to the development of OSA in many patients. Enlargement of soft t...
متن کاملPathogenesis of obstructive and central sleep apnea.
Considerable progress has been made over the last several decades in our understanding of the pathophysiology of both central and obstructive sleep apnea. Central sleep apnea, in its various forms, is generally the product of an unstable ventilatory control system (high loop gain) with increased controller gain (high hypercapnic responsiveness) generally being the cause. High plant gain can con...
متن کاملThe pathogenesis of obstructive sleep apnea.
Obstructive sleep apnea (OSA) is a major source of cardiovascular morbidity and mortality, and represents an increasing burden on health care resources. Understanding underlying pathogenic mechanisms of OSA will ultimately allow for the development of rational therapeutic strategies. In this article, we review current concepts about the pathogenesis of OSA. Specifically, we consider the evidenc...
متن کاملMolecular and physiologic basis of obstructive sleep apnea.
Obstructive sleep apnea-hypopnea syndrome occurs because of various combinations of anatomic, mechanical, and neurologic anomalies that jeopardize ventilation only when normal state-dependent reductions in drive to upper airway respiratory muscles and pump muscles occur. A well thought out and carefully described infrastructure of the normal and abnormal physiology in persons with OSAHS has bee...
متن کاملSleep Apnea: Pathogenesis, Diagnosis, and Treatment
The processes that control respiration differ substantially across the 3 sleep/awake states (awake, rapid eye movement sleep, and non-rapid-eye-movement sleep). This has important implications for clinicians caring for patients with and without underlying cardiopulmonary disease, because we now recognize an array of sleep-related breathing disorders. Some diseases, such as sleep apnea, are slee...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2011
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201108-1573ed